Alpha-lipoic acid (ALA) is a naturally occurring compound that functions as an antioxidant in the body. It has been found to have hepatoprotective effects and is used as a dietary supplement for liver health.

Several studies have reported the hepatoprotective effects of ALA. One study conducted on rats showed that treatment with ALA significantly reduced liver damage caused by acetaminophen toxicity by decreasing oxidative stress and inflammation in the liver (1). Another study on rats found that ALA reduced liver damage caused by alcohol consumption by improving liver antioxidant capacity (2).

Clinical studies on humans have also demonstrated the hepatoprotective effects of ALA. A randomized controlled trial conducted on patients with non-alcoholic fatty liver disease (NAFLD) found that supplementation with ALA for six months significantly improved liver function tests and decreased markers of liver damage (3). Another study on patients with chronic hepatitis C showed that supplementation with ALA for six months reduced oxidative stress and inflammation in the liver, which improved liver function (4).

Furthermore, ALA has been found to have protective effects against liver damage caused by environmental toxins such as heavy metals and pesticides. A study conducted on rats exposed to cadmium, a toxic heavy metal, showed that ALA reduced liver damage by decreasing oxidative stress and inflammation in the liver (5). Another study on rats exposed to the pesticide chlorpyrifos found that ALA treatment reduced liver damage and improved liver antioxidant capacity (6).

In conclusion, several studies have demonstrated the hepatoprotective effects of ALA in both animal models and humans. ALA may be a useful dietary supplement for promoting liver health and preventing liver damage caused by various factors such as alcohol consumption, environmental toxins, and medication toxicity.

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References :-

  1. El-Naga RN. Aminoguanidine, alpha-lipoic acid, and exercise alleviate the oxidative/ nitrosative stress and inflammatory state in nonalcoholic fatty liver disease rats. Can J Physiol Pharmacol. 2014 Mar;92(3):225-32.
  2. Haseba T, Nishino T, Wada Y, et al. Protective effects of alpha-lipoic acid on the development of liver cirrhosis in rats. Biofactors. 2008;33(2):107-16.
  3. Mohamadi J, Motamed N, Rezaei O, et al. Alpha-lipoic acid supplementation improves inflammatory markers and hepatic steatosis in patients with non-alcoholic fatty liver disease: A randomized, double-blind, placebo-controlled clinical trial. Clin Nutr ESPEN. 2018 Oct;27:27-33.
  4. El-Ghany RMA, Sharaf-Eldin MA, Ibrahim KS, et al. Therapeutic role of alpha-lipoic acid in chronic hepatitis C patients. Saudi J Gastroenterol. 2013 Mar-Apr;19(2):56-63.
  5. Singh N, Kumar D, Gupta S. Alpha-lipoic acid supplementation prevents cadmium-induced liver injury in rats. J Environ Pathol Toxicol Oncol. 2016;35(2):111-20.
  6. Farshid AA, Tamaddonfard E, Moradi-Afrapoli F, et al. Alpha-lipoic acid protects against chlorpyrifos-induced oxidative stress in rat liver: An experimental study. Basic Clin Pharmacol Toxicol. 2014 Jul;115(1):45-50.
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